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Major challenges in NDDS include biocompatibility, biodegradability, immune-evasion efficacy, solubility and stability in biological environments, and the potential for off-target effects

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Studies on dermal fibroblasts have documented up to 70% increases in collagen I production at optimal concentrations of 1 nanomolar

For example, solid microneedles use a poke-and-patch strategy, whereas dissolving microneedles directly release encapsulated drugs upon dissolution within the skin (He et al., 2019)

B cells play a complex, dual role in the onset and progression of ALD