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Lifestyle risk factors known to decrease sperm quality include: Cigarette smoking Alcohol consumption Chronic stress Nutritional deficiencies

REDEFINE is a phase 3 clinical program that will evaluate the efficacy and safety of CagriSema in patients with overweight or obesity using CagriSema for a period of 68 weeks in a larger patient population

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Low levels of serum androgens have been reported to correlate with increased expression of the circulating pro-inflammatory cytokines IL-1, IL6 and TNF- which is reported to contribute to the decrease of testosterone production via Toll-like-Receptor (TLR) pathway activation (Samir et al., 2017

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