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However, the leap from a mouse model of nerve injury to human treatment of complex neurological conditions is enormous

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Peer review Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work

Each type of NAD therapy has a different absorption mechanism, a different body of evidence behind it, and a different track record for actually raising intracellular NAD+ levels

The SURMOUNT-5 trial showed that maximum-dose tirzepatide produces about 47% more weight loss than maximum-dose semaglutide, so they are clearly not equivalent at their respective maximums