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While the efficacy data impressed investors and clinicians alike, the safety and tolerability profile revealed some challenges

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Dose-Response at 24 Weeks The 24-week data illustrate the dose-response relationship during the mid-treatment phase: Phase 3 Results: Extended Timeline Data TRIUMPH-4 (68 Weeks) The TRIUMPH-4 Phase 3 trial extended the treatment duration to 68 weeks in 445 adults with obesity and knee osteoarthritis

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Managing Expectations with Semaglutide Treatments Semaglutide treatment generally initiates with minimal effective dosing that increases gradually based on patient response and tolerance assessments