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Annu Rev Biochem (1980) 49:593626

Risk Factors: High doses (2000mg+ daily) Long-term continuous use (6+ months) Pre-existing liver conditions Alcohol consumption use Symptoms to Watch: Unusual fatigue weakness Yellowing of skin/eyes (jaundice) Dark urine color Severe abdominal pain Loss of appetite 2

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Conversely, longer or slightly thicker needles can cause bruising, more pain and erratic absorption, impacting the therapeutic effect of semaglutide