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Yet side effects of these drugsparticularly nausea and vomitingare common in both clinical trials 9 and real world data 10

In a review study from Denmark, also analyzed by Fessel, dementia risk was lowered by 53% when patients with Type 2 diabetes on GLP-1s were compared to patients on placebo

Summary of GLP-1 Hypoglycemic Drugs GLP-1 Activating Drugs directly stimulate GLP-1 receptors, offering benefits like improved insulin secretion, glucagon suppression, appetite control, and weight loss

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Oral bioavailability studies in rats show systemic effects even when administered per os, suggesting meaningful absorption through the GI mucosa