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Gastrointestinal Effects: By slowing gastric emptying, semaglutide helps to reduce postprandial glucose excursions and contributes to the sensation of fullness

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Medications requiring particular consideration with Rybelsus include: Levothyroxine (thyroid hormone replacement) - monitor thyroid function as semaglutide may increase levothyroxine exposure Warfarin and other anticoagulants - monitor INR when initiating semaglutide Insulin and sulfonylureas (increased risk of hypoglycaemia, dose adjustment may be needed) According to the Rybelsus Summary of Product Characteristics (SmPC), patients should take the medication correctly: on an empty stomach with no more than 120ml of water, swallow the tablet whole, and wait at least 30 minutes before any food, drink, or other oral medications