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The 3-hydroxy oxidations are catalyzed by NAD + -dependent hydroxysteroid dehydrogenases of which 3-hydroxysteroid dehydrogenase 2 (HSD3B2) is the most prevalent in gonads and adrenal gland
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Furthermore, attenuation of uremic toxin-induced damage by vitamin D activated by the bioengineered kidney tubules was demonstrated (Mihajlovic et al
It encompasses several pathways, including neurological (vagus nerve), hormonal, immunological, and microbiome-mediated signals, all of which play a critical role in maintaining physiological homeostasis and responding to systemic stresses (Sasso et al., 2023)
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