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Given the study did not show a significant difference in fibrosis stage, semaglutide has not yet been FDA approved for NASH

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SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

Cagrilintide and semaglutide work through different mechanisms and have different dosing schedules: Cagrilintide: Amylin receptor agonist Escalation: 0.6 mg 1.2 mg 2.4 mg weekly Three-step titration over 8 weeks Semaglutide: GLP-1 receptor agonist Escalation: 0.25 mg 0.5 mg 1.0 mg 1.7 mg 2.4 mg weekly Five-step titration over 16-20 weeks When combined in CagriSema, both peptides are dosed at 2.4 mg weekly, representing the maximum studied dose for each component