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The STEP 1 trial, published in the New England Journal of Medicine, showed that this sustained caloric reduction led to an average weight loss of 14.9% of body weight over 68 weeks

Kumar et al., 2015

Blood vessels matter because angiogenesis improves oxygen and nutrient delivery to injured tissue, which supports wound, tendon, muscle, and gut lining repair in preclinical models

They worked: in research models they reliably stimulated growth hormone release from pituitary somatotrophs through binding the GHS-R1a (ghrelin receptor)