This phosphorylation, which occurs via the JNK pathway, is considered to be crucial as it modifies FOXO4, preparing it for its role in the cell's nucleus
The inclusion criteria for the patients group consisted of mild to severe DE in in-patients aged 60 years with recurrent depressive disorder (RDD, F33.0-F33.3), bipolar disorder (BD, F31.3, F31.4), or single DE (F32.0-F32.2) by ICD-10
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Since HEDS contains no glutathione moiety, alterations at the scaffold site could provide further insights regarding GSSEtOH as a potential reaction intermediate