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Studies suggest that up to 25 to 40% of the weight lost during GLP-1 therapy may come from lean mass, primarily skeletal muscle, if active steps are not taken to preserve it [23]

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Biomedical Journal of Scientific and Technical Research, 2025

Smith, A.C.W

GLP-1 induced cAMP accumulation was quantified in HEK293 cells transfected with plasmids expressing either (C) the GLP-1R or (D) a GIPR/GLP-1R chimeric protein where the GLP-1R 7TM domains are fused in-frame with the GIP-R ectodomain