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cGMP facilitates smooth muscle relaxation in blood vessels either by enhancing Ca 2+ extrusion or by reducing the sensitivity of the myofilaments to Ca 2+ [102]

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Using cell culture models and molecular analysis techniques including cDNA microarray, RT/real-time PCR, and Western blotting, researchers demonstrated that BPC-157 treatment upregulates GHR expression in a dose- and time-dependent manner at both the mRNA and protein levels

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