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32,33 In both Japanese and White populations, several studies have shown that self-reported CPD are lower for smokers who carry CYP2A6 variant alleles that code for little or no active CYP2A6 enzyme compared to smokers who carry none of these variant alleles

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For a burning cigarette to ignite a substrate (i.e., sustained smouldering and/or flame combustion of the substrate), three steps have to take place: first, thermal contact must occur between the cigarette and the substrate

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