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Keep in mind also that when coffee is administered to laboratory animals, in moderate but repeated doses similar to what humans consume, it produces pathological changes in the gastrointestinal tract and ultimately ulcer formation.122 OTHER GASTROINTESTINAL RISK FACTORS Temperature Most people drink their coffee piping hot, and the resulting increase in gastrointestinal temperature has been shown to contribute to upper GI tract disorders.123 Food Allergy or Intolerance Some individuals appear to be allergic to coffee (or possibly the chemicals it is treated with), and this can increase the adverse effects associated with the beverage.124 The Melatonin Connection: Intriguing New Research In Chapter 3, I described the critical role played by melatonin in regulating immunity and sleep